accident
adversity
blow
calamity
casualty
cataclysm
catastrophe
collision
contretemps
crack-up
crash
disaster
grief
ill hap
infelicity
misadventure
misfortune
mishap
nasty blow
pileup
shipwreck
shock
smash
smashup
staggering blow
tragedy
wreck
chance
fortune
hazard
luck
bereavement
blunder
chutzpah
coincidence
drawback
fatality
fortuity
happen
hindrance
indiscretion
infatuation
misapprehension
miscalculation
miscarriage
misgiving
misunderstanding
perplexity
pestilence
plight
predicament
setback