accident
adversity
affliction
bane
blow
bugbear
burden
casualty
cataclysm
catastrophe
collapse
collision
contretemps
crack-up
crash
cross
crushing burden
curse
death
desolation
destruction
devastation
disaster
disease
distress
downfall
evil
exigency
extremity
fatal accident
fatality
grief
grievance
hardship
harm
ill hap
infelicity
infliction
misadventure
mischance
misery
misfortune
bad luck
act of god
apocalypse
famine
force majeure
inevitable accident
kiss of death
meltdown
plague
tidal wave
tsunami
unavoidable casualty
vis major
visitation
conflict
defeat
disgrace
disturbance
doom
humiliation
mischief
oppression
peril
sickness
temptation
woe
amity