adverse circumstances
adversity
affliction
aggravation
alteration
alternation
annoyance
asperity
blight
bummer
care
chain of circumstances
chain reaction
change
changeability
changes
chapter of accidents
chop and change
concatenation of events
contrasts
cross
curse
difficulties
difficulty
diversity
downer
feast and famine
fluctuation
flukiness
flux
hard knocks
hard life
hard lot
hardcase
hardness
hardship
inconstancy
innovation
ins and outs
interchange
irritation
mischance
misfortune
mutability
mutation
novelty
oscillation
mutableness
variation
buffetings
chirruping
contrariety
cross-fire
drip-drip
ebb
efflux
goading
happen
inclemency
indifferentism
inquietude
manoeuvring
moiti
ordinariness
plash
plashing
prophesy
quarrelling
reiteration
soughing
teetotaller
unfamiliarity
vicissitudes