aching heart
affliction
agony
agony of mind
anguish
bale
bitterness
bleeding heart
broken heart
brokenheartedness
care
crushing
depression
depth of misery
desolation
despair
dole
extremity
grief
heartbreak
heartbrokenness
heartsickness
heartsoreness
heavy heart
infelicity
melancholia
melancholy
misery
prostration
regret
rue
sadness
sorrow
suicidal despair
woe
wretchedness
dolor
dolour
bereavement
bewilderment
discouragement
disillusionment
faintness
foreboding
frustrations
homesickness
hopelessness
loneliness
nausea
privation
remorse
self-doubt
sleeplessness
tiredness
tribulation
unease
unhappiness